, Ministerul Dezvoltarii Regionale [section] i Locuintei, 'Reuniune informala a ministrilor responsabili cu domeniul locuirii', [Online] available at http://www.mdrl.ro/printeaza.
2A), which was mainly due to the overexpression of mdr3 gene, whereas mdrl
gene expression was not up-regulated in P388/DOX cells compared to the sensitive cells (Fig.
Minimally modified phosphodiester antisense oligodeoxyribonucleotide directed against the multidrug resistance gene mdrl
The role of prostaglandin E receptor-dependent signaling via cAMP in Mdrl
b gene activation in primary rat hepatocyte cultures.
Internal duplication and homology with bacterial transport proteins in the mdrl
(P-glycoprotein) gene from multidrug-resistant human cells.
2-acetylaminofluorene up-regulates rat mdrl
b expression through generating reactive oxygen species that activate NF-kappa B pathway.
showed that MDRl
was expressed in epithelial cancers derived from various organs/tissue (colon, liver, kidney) and it was found in hematopoeitic cancers (AML, ALL lymphoma) and solid tumors (breast and ovary cancer) (Goldstein et al.
It is often related to the overexpression of a 170kDa plasma membrane glycoprotein (P-gp) encoded by the mdrl
Decreased mutation rate for cellular resistance to doxorubicin and suppression of mdrl
gene activation by the cyclosporin PSC 833.
Inhibition of P-glycoprotein expression and reversal of drug resistance of human hepatoma HepG2 cells by multidrug resistance gene (mdrl
) antisense RNA.