Each group received a different treatment: 0.1 mg/kg AmB, 10 pg mDSE, 0.1 mg/kg AmB, and 10 pg mDSE, or saline.
Treatment with Low-Dose AmB Plus mDSE Increases Survival in Mice with Systemic Candidiasis.
The administration of 10 pg of mDSE alone did not affect the survival of mice infected with 5 x [10.sup.5] CFU.
Treatment with AmB Plus mDSE Ameliorates the Histopathology Induced by Systemic Candidiasis.
The histopathological changes in mice infected with Ca07-387 and treated with mDSE were similar to those of untreated mice; their kidneys showed necrosis in the pelvic area (Figure 2(c)) and abundant hyphae (Figure 2(h)).
Effects of Low-Dose AmB and mDSE on Kidney Cytokines, Systemic IL-6, and Hepcidin on Mice with Systemic Candidiasis.
We used this model to evaluate the efficacy of low-dose AmB supplemented with mDSE for the treatment of systemic candidiasis.
Mice that were treated with AmB alone had higher concentrations of the pro-inflammatory cytokines TNF-[alpha] and IL-6 in their kidneys, but lower concentrations of IFN-[gamma], compared to mice that were treated with AmB plus mDSE. These results suggest that mice treated only with AmB have increased inflammation but lower protection from C.
Serum hepcidin was significantly higher on day 8 in mice that received AmB plus mDSE, compared with mice that only received AmB; in the latter group, serum hepcidin increased its concentration only after day 15.