MEF2

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Acronym	Definition
MEF2	Myocyte Enhancer Factor 2
MEF2	Mitochondrial Elongation Factor-G (genetics)

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References in periodicals archive ?

A dominant-negative form of transcription factor MEF2 inhibits myogenesis.

Expression profiles of circular RNAs in sheep skeletal muscle

A hallmark of the MEF2 proteins is their propensity to associate with cell-specific and signal-dependent cofactors.

Myocyte Enhancer Factor-2A Gene Mutation and Coronary Artery Disease

Activation of slow fiber-specific transcription appears to be mediated by a combinatorial mechanism involving members of the NFAT and MEF2 family of transcriptional regulators.

Calcineurin-NFAT signaling and neurotrophins control transformation of myosin heavy chain isoforms in rat soleus muscle in response to aerobic treadmill training

This polypeptide, CHAMP (cardiac helicase activated by MEF2 protein), bears striking resemblance to a number of other helicase proteins and appears to play a role in RNA processing and transcriptional control in heart muscle.

University of Texas obtains United States patent

The activity was most pronounced on promoters containing DNA binding sites for MEF2, a transcription factor important for skeletal muscle differentiation.

Abstracts of papers presented at the 2004 collegiate meetings

Won et al., "Myocardial infarction-associated SNP at 6p24 interferes with MEF2 binding and associates with PHACTR1 expression levels in human coronary arteries," Arteriosclerosis, Thrombosis, and Vascular Biology, vol.

The Impact of CRISPR/Cas9 Technology on Cardiac Research: From Disease Modelling to Therapeutic Approaches

The Mb pathway involves signaling of the [Ca.sup.2+] concentration variance from muscle cells being transducted to nuclear factor of activated T cells (NFATc1) and myocyte enhancer factor 2 (MEF2) in the nucleus by activating calcineurin (CaN) or calmodulin- dependent protein kinases (CaMK); this modulates the transcription of downstream genes, including the Mb gene [16,17].

Studies on meat color, myoglobin content, enzyme activities, and genes associated with oxidative potential of pigs slaughtered at different growth stages

For example, chemical inhibition of Jak2 downregulates the transcription factors myoD and MEF2, and target knockdown of Jak2 by siRNA leads to downregulated myoD and MEF2 target gene transcription [94].

Granulocyte Colony-Stimulating Factor and Its Potential Application for Skeletal Muscle Repair and Regeneration

Jain, "Tumor necrosis factor alpha-mediated reduction of KLF2 is due to inhibition of MEF2 by NF-[kappa]B and histone deacetylases," Molecular and Cellular Biology, vol.

Pretreatment Donors after Circulatory Death with Simvastatin Alleviates Liver Ischemia Reperfusion Injury through a KLF2-Dependent Mechanism in Rat

The dataset contains 24 sequences, as well as five motifs (Mef2, Tef, Srf, Sp1, and Myf), which play an important role in muscle regulation.

A New Algorithm for Identifying Cis-Regulatory Modules Based on Hidden Markov Model

Franchini, "Focal adhesion kinase mediates MEF2 and c-Jun activation by stretch: role in the activation of the cardiac hypertrophic genetic program," Cardiovascular Research, vol.

An altered pattern of myocardial histopathological and molecular changes underlies the different characteristics of type-1 and type-2 diabetic cardiac dysfunction

Calcineurin regulates expression of the myogenin gene at the transcriptional level by activating MEF2 and MyoD transcription factors [87].