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A dominant-negative form of transcription factor MEF2 inhibits myogenesis.
A hallmark of the MEF2 proteins is their propensity to associate with cell-specific and signal-dependent cofactors.
Activation of slow fiber-specific transcription appears to be mediated by a combinatorial mechanism involving members of the NFAT and MEF2 family of transcriptional regulators.
This polypeptide, CHAMP (cardiac helicase activated by MEF2 protein), bears striking resemblance to a number of other helicase proteins and appears to play a role in RNA processing and transcriptional control in heart muscle.
The activity was most pronounced on promoters containing DNA binding sites for MEF2, a transcription factor important for skeletal muscle differentiation.
Won et al., "Myocardial infarction-associated SNP at 6p24 interferes with MEF2 binding and associates with PHACTR1 expression levels in human coronary arteries," Arteriosclerosis, Thrombosis, and Vascular Biology, vol.
The Mb pathway involves signaling of the [Ca.sup.2+] concentration variance from muscle cells being transducted to nuclear factor of activated T cells (NFATc1) and myocyte enhancer factor 2 (MEF2) in the nucleus by activating calcineurin (CaN) or calmodulin- dependent protein kinases (CaMK); this modulates the transcription of downstream genes, including the Mb gene [16,17].
For example, chemical inhibition of Jak2 downregulates the transcription factors myoD and MEF2, and target knockdown of Jak2 by siRNA leads to downregulated myoD and MEF2 target gene transcription .
Jain, "Tumor necrosis factor alpha-mediated reduction of KLF2 is due to inhibition of MEF2 by NF-[kappa]B and histone deacetylases," Molecular and Cellular Biology, vol.
The dataset contains 24 sequences, as well as five motifs (Mef2, Tef, Srf, Sp1, and Myf), which play an important role in muscle regulation.
Franchini, "Focal adhesion kinase mediates MEF2 and c-Jun activation by stretch: role in the activation of the cardiac hypertrophic genetic program," Cardiovascular Research, vol.
Calcineurin regulates expression of the myogenin gene at the transcriptional level by activating MEF2 and MyoD transcription factors .
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- meets their match
- meets their Waterloo
- meets them halfway
- meets them in the flesh
- meets up
- meets up with
- meets us halfway
- meets us in the flesh
- meets Waterloo
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- Meezan Islamic Income Fund
- MEF Weather Support Team
- MEF-2 interacting transcription repressor (MITR) protein
- MEF2-interacting transcription repressor MITR
- MEF2D/DAZAP1 fusion
- mefenamic acid
- mefenamic acid
- Meff Renta Fija
- Meff Renta Variable