Human APP gene expression significantly (P <0.01) decreased mean mEJPs frequency by 41% compared to the control.
Distribution of mEJPs latencies in all lines were best-fitted with a monoexponential equation predicted by the Poisson model well, thus confirming that under all experimental conditions, the random nature of spontaneous quantal release is not altered.
It was observed that the mean peak amplitude and the rise time and decay time of mEJPs, obtained in the control line, were not significantly changed in APP, APP+BACE, and A[beta] lines (Table 2).
Accordingly, at Brp mutant, evoked vesicle release was depressed; however, the mEJPs frequency was not significantly altered .
Caption: Figure 5: mEJPs recoded at muscle fiber 6 and 7 neuromuscular junctions from transgenic Drosophila melanogaster larvae.
Caption: Figure 6: Distribution of mEJPs amplitudes recorded at muscle fiber 6 and 7 neuromuscular junctions from transgenic Drosophila melanogaster larvae.