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MEN 2BMultiple Endocrine Neoplasia Syndrome Type 2B
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As stated, although the common MEN 2B mutation in exon 16 (M918T) removes a Fok I site and could therefore be easily analyzed by restriction digest, exons 10 and 11 harbor a variety of mutations in multiple codons in MEN 2A and MTC patients (see Table 1 in reference 11).
We have adapted this technique to detect mutations in exons 10, 11, and 16 associated with inherited MTC (MEN 2A, MEN 2B, or FMTC).