MEN1


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AcronymDefinition
MEN1Multiple Endocrine Neoplasia Type 1 (disorder)
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During this study, mutations in the MEN1 gene were identified in two paraffin-preserved sporadic enteropancreatic neuroendocrine tumors.
Given these findings and the clinical suspicion of MEN1, the study was completed with a CT scan of the neck, chest, abdomen, and pelvis, which showed a hypervascular heterogeneous mass with lobulated and well-defined edges of 6.8 x 7.7 x 6.4 cm in the tail of pancreas, plus another mass of similar characteristics of 6 x 4.2 cm in the uncinate process and at least three more pancreatic focal lesions of less than 1 cm on the head and neck of pancreas (Figure 2).
The tumor suppressor function of menin was supported when germline inactivating mutations of MEN1 were found in MEN1 cases.
Type-II ECL-cell NETs occur in patients with MEN1 or Zollinger-Ellison syndrome.
Thakker, "Multiple endocrine neoplasia type 1 (MEN1) and type 4 (MEN4)," Molecular and Cellular Endocrinology, vol.
While the underlying mechanism of this finding is largely unknown, this phenomenon is attributed to the status of pseudohypoxia resulting in HIF-1[alpha] increase in the setting of VHL disease, (15) since positivity for inhibin has not been observed in other clear cell NETs associated with MEN1 syndrome.
While the mutated gene is not identified in many cases, there are kindreds in which either MEN1 or HRPT2 have been identified.
However, retention of the normal MEN1 allele in these cells indicates that they are still nonneoplastic in nature.
Molecular studies show a high incidence of loss of heterozygosity at the MEN1 gene in all subtypes of primary pulmonary neuroendocrine carcinomas.
Furthermore, only about one- quarter (27%) of women know that benefits paid from life insurance are not taxable versus 38% of men1.