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MEN1Multiple Endocrine Neoplasia Type 1 (disorder)
References in periodicals archive ?
What is the Role for Genetic Counseling with MEN1 Gene Testing?
ATRX, DAXX and MEN1 mutations have better prognosis.
Diagnosis of MEN syndromes is generally based on clinical findings, but demonstration of MEN-associated variations in MEN1 [7] (MEN-1) or RET (MEN-2) by direct DNA sequencing can confirm the diagnosis (4,28).
MEN1 Colin Firth (left) 2 Orlando Bloom 3 Alan Rickman 4 Sean Connery 5 Sean Bean 6 Hugh Grant 7 Colin Farrell 8 Liam Neeson 9 Robert Carlyle 10 Ewan McGregor
88,89) Germ line MEN1 mutations occur in multiple endocrine neoplasia 1 syndrome patients, 65% of whom develop PanNETs.
Germline mutations of the MEN1 gene in Korean families with multiple endocrine neoplasia type 1 (MEN1) or MEN1-related disorders.
The recently identified MEN1 gene (1-3) encodes a putative tumor suppressor protein termed menin.
Type-II ECL-cell NETs occur in patients with MEN1 or Zollinger-Ellison syndrome.
While the underlying mechanism of this finding is largely unknown, this phenomenon is attributed to the status of pseudohypoxia resulting in HIF-1[alpha] increase in the setting of VHL disease, (15) since positivity for inhibin has not been observed in other clear cell NETs associated with MEN1 syndrome.
Age y Mean, 55 (range, 18-79) Sex Female 63 (39) Male 97 (61) Associated syndrome MEN1 11 (7) Othera 2 (1) Functional tumors 25 (16) Tumor size, cm Mean, 4.
Approximately 60% of those with a germline mutation of the MEN1 gene, located on 11q, eventually develop a pancreatic NET.