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MEN2BMultiple Endocrine Neoplasia, Type IIB
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PTx was recommended in the first year of life for MEN2B (M918T, A883F), before 5 years of age for subjects with level C (634 mutations) and also for level B (609, 611, 618, 620, 630, 631 mutations).
Multiple mucosal neuromas are pathognomonic for MEN2B (Mucosal Neuroma Syndrome), an autosomal dominant disease characterized by medullary thyroid carcinoma, pheochromoctyoma, and gastrointestinal ganglioneuromatosis.
(9) In tumours associated with mutations at the 918 allele (MEN2B), early aggressive behaviour with distant metastatic spread is typical (10) and cases of inherited MTC have been reported as early as 2 months of age.
Multiple endocrine neoplasia type 2 (MEN2) is an autosomal dominant cancer syndrome that can be divided into three clinical subtypes: MEN2A, MEN2B, and familial medullary thyroid carcinoma (MTC).
Recently it was meant to be Mark Henderson from failed Irish boyband Men2B.
And to prove it, Eddie McGuinness has taken the showbiz scalpel to his band Men2B.