MEN2a


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Related to MEN2a: MEN2B
AcronymDefinition
MEN2aMultiple Endocrine Neoplasia, Type 2a (genetic disorder)
References in periodicals archive ?
Put simply, that meant that she might not be alone, because MEN2A is inherited.
MTC (and other thyroid tumours) have been shown to be genetically linked to mutations in the RET (REarranged during Transfection) proto-oncogene (situated at 10q22 (3,4)), which plays a pivotal role in at least four clinical syndromes (MEN2A and MEN2B, familial medullary thyroid carcinoma (FMTC) and Hirschsprung's disease (HSCR)) in a unique 'switch on, switch off' manner.
Pasini et al., "RET activation by germline MEN2A and MEN2B mutations," Oncogene, vol.
Multiple endocrine neoplasia type 2 (MEN2) is an autosomal dominant cancer syndrome that can be divided into three clinical subtypes: MEN2A, MEN2B, and familial medullary thyroid carcinoma (MTC).
Moreover, germline RET mutations are associated with the three variants of the inherited cancer syndrome, multiple endocrine neoplasia type 2 (MEN2A, MEN213, and FMTC).
Mutations in the RET proto-oncogene are associated with MEN2A and FMTC.