MEOVMaximum Expected Operating Value
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As compared to saline, MeOV at doses 15 and 30 mg/kg significantly elevated the response latency duration to a maximum rise of 20.33 2.75 s in hot plate test, while itincreased to a maximum of 18.333.38 s in tail immersion test as shown in figures 3 and 4 respectively.
This peripheral response is generated due to release of various local inflammatory mediators including prostaglandins, cytokines, histamine, substance P, bradykinin and others [19] MeOV displayed a significant decline in the number of writhes at dose 15 and 30 mg/kg as compared to the saline treated group while 7.5 mg/kg dose failed to produce any significant effects.
In both hot plate and tail flick test MeOV extract prolonged the response latencies at 15 and 30 mg/kg with no notable effects at 7.5 mg/kg.
Similar results were obtained in tail clip test where MeOV extract produced a marked extension in the latency to respond when rodent's tail was clogged by a metal artery clip.