Treatment of MgIG Blocked Chronic Plus Binge Ethanol Feeding-Induced Neutrophil Infiltration and Activation in the Liver.
Treatment of MgIG Prevented Inflammatory Cytokine and Chemokine Production.
MgIG Blocked Chronic Plus Binge Ethanol Feeding-Induced Neutrophil ROS Production and Oxidative Stress in the Liver.
The treatment of MgIG significantly blocked the activation and infiltration of neutrophils in the chronic plus binge model.
Here, we adopted the chronic plus binge feeding model to evaluate the hepatoprotective effects of MgIG on ALD and possible mechanisms involved, especially how MgIG influenced the behavior of neutrophils.
MgIG, a derivative of glycyrrhizic acid, was the extraction of the plant Glycyrrhiza glabra, with potential anti-inflammatory and antioxidant effects.
In summary, this study demonstrated markedly hepatoprotective effects of MgIG against chronic binge ethanol-induced liver injury.
Caption: Figure 1: Protective effect of MgIG treatment against chronic plus binge ethanol feeding-induced hepatic injury.
Caption: Figure 2: MgIG prevents chronic plus binge ethanol feeding-induced neutrophil infiltration in the liver.
Caption: Figure 3: MgIG prevents chronic plus binge ethanol feeding-induced proinflammatory mediator expression.