The REDUCE trial did not show a statistically significant increased risk for patients using dutasteride for detectable Gleason 7-10 cancers (MHRR: 0.95, 95% CI 0.79-1.14), as did the CombAT trial (MHRR: 0.63, 95% CI 0.38-1.04).
The REDUCE trial showed no statistically significant increased risk for patients using dutasteride for detectable Gleason 8-10 cancers (MHRR: 1.53, 95% CI 0.86-2.73), as did CombAT (MHRR: 0.59, 95% CI 0.26-1.31).
Rather than reissuing the marked instruction, however, the machine issues the implicit branch-and-link instruction with a PC address equal to the informing memory operation (so that the MHRR is loaded with the appropriate return address).
This tool uses a single miss handler containing roughly 20 instructions to increment a hash table entry based on the branch-and-link return address (available in the MHRR), thus distinguishing all static references.
The instruction fetcher uses the MHRR to predict the return address from the miss handler, similar to the way that a return address stack is used to predict the target of a procedure return.
Upon a cache miss, we use the contents of the MHRR register to uniquely identify the static memory reference instruction which suffered the miss; based on this instruction address, we perform a hash table lookup to find a unique counter associated with this instruction and increment its miss count.
8) Writers have found that all roads lead to the Diagnostic and Statistical Manual of Mental Disorders (the DSM), that "charter document" that lies under every MHRR rock; all of the writers seem to have (re)discovered that while the DSM is considered authoritative medicine to many healthcare professionals and scientists, it's a house of cards from a rhetorician's point of view--a biased social construction fraught with validity and reliability issues.
Four foundational anthologies--by Lee Odell and Dixie Goswami (1985), Carolyn Matalene (1989), Charles Bazerman and James Paradis (1991), and Rachel Spilka (1993)--were pivotal in shaping early work in MHRR. They offered my generation of MHRR enthusiasts the critical doorways, invitations, permissions, validations, endorsements, and challenges for us to try to map, explore, and analyze--even try to help--various types of highly specialized professional discourse communities.
In the mid-1980s, while completing my belated doctoral work at the University of Oklahoma, I stumbled into MHRR quite by accident when, as I detailed in my contribution's introduction to Barbara Heifferon and Stuart Brown's 2008 anthology, my clinical psychologist father-in-law casually suggested to my colleague (and technical writing specialist) David Mair and me over a bibulous brunch that we might try to "figure out why" mental health practitioners had "so damn much trouble communicating with each other" about their patients via patient records.
David and I worked for the next several years (him still from Oklahoma, me at that point from Virginia) on a book in which we explored MHRR more fully with the help of clinician co-author Pamela Fischer.
I did not know until then that anyone else in rhetoric and writing was working in MHRR, nor did Lucille.
Looking at everything that has been written since she did her MHRR work in the mid-80s and early 90s, tracking citations, quotations, acknowledgments, and such, it is an inescapable fact that by far the most influential first-work in MHRR was done by Lucille Parkinson McCarthy.