Compared with the mothers from the EDEN cohort with biomarker concentrations but missing placental weight, the concentrations of 2,5 dichlorophenol; sum of dichlorophenols; triclosan; methyl, ethyl, and propyl paraben; sum of parabens; and low-molecular-weight phthalate metabolites (MEP, MBP, MiBP
) were lower in our study population (p-values for Wilcoxon rank-sum test <0.10).
Despite this gloomy assessment, MIBP
makes the following delusional assertion "that the supply of rare earth materials for U.S.
BPA was obtained from TCI Europe (Zwijndrecht, Belgium), while MiBP
, MnBP, and MEHP were from Orchid Cellmark (New Westminster, BC, Canada).
IBAS follows the Office of MIBP
methodology in evaluating risk to the industrial base by assessing both the fragility and criticality of a capability or product.
While Matthews has established that MIBP
does indeed decline during rip-ening, the most effective means for keeping it low is to leave enough buds for a balanced vine, potentially supplemented by leaf pulling immediately postset rather than the common practice of attempting to make up for under-cropping by extending maturity.
In particular, MIBP
has the organizational visibility and access to policy and investment levers to enable more coherent and integrated approaches to maintaining the full suite of necessary defense manufacturing enterprise capabilities.
The following 11 phthalate metabolites were measured: mono-ethyl phthalate (MEP), mono-iso-butyl phthalate (MiBP
), mono-n-butyl phthalate (MnBP), 3OH-mono-n-butyl phthalate (OH-MnBP), mono-benzyl phthalate (MBzP), mono-(2-ethylhexyl) phthalate (MEHP), mono-(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP), mono-(2-ethyl-5-oxohexyl) phthalate (MEOHP), mono-hydroxy-iso-nonyl phthalate (MHiNP), mono-oxo-isononyl phthalate (MOiNP), and mono-n-octyl phthalate (MOP).
Adjustment for year of birth substantially attenuated estimates of association for MEP, MiBP
, MnBP, DEHP, and DiNP; however, associations for DEHP remained statistically significant in year-adjusted models (Table 3; see also Table S1).
By contrast, we hypothesized that metabolites of antiandrogenic phthalates [e.g., mono-isobutyl phthalate (MiBP
) and MCPP, metabolites of di-isobutyl phthalate (DiBP) and of several HMWPs (e.g., MCPP)], and the DEHP metabolites MEHP, mono(2-ethyl-5-oxyhexyl) phthalate (MEOHP), mono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP), MECPP (Borch et al.
The targeted phthalate metabolites were monoethyl phthalate (MEP), mono-n-butyl phthalate (MBP), mono-isobutyl phthalate (MiBP
), mono(2-ethyl-5-carboxypentyl) phthalate (MECPP), mono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP), mono(2-ethyl-5-oxohexyl) phthalate (MEOHP), mono(2-ethylhexyl) phthalate (MEHP), monobenzyl phthalate (MBzP), monocarboxyisooctyl phthalate (MCOP), mono(3-carboxypropyl) phthalate (MCPP), and monocarboxy-isononyl phthalate (mCnP).
Mono-isobutyl phthalate (MiBP
) and DEHP metabolites tended to be associated with reduced [FEV.sub.1]% (p between 0.12 and 0.26, Table 4, Figure 1B).
We quantified urine concentrations of monoethyl phthalate (MEP), mono-n-butyl phthalate (MnBP), mono-isobutyl phthalate (MiBP
), mono(3-carboxypropyl) phthalate (MCPP), monobenzyl phthalate (MBzP), and four metabolites of DEHP: mono(2-ethylhexyl) phthalate (MEHP), mono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP), mono(2-ethyl-5-oxohexyl) phthalate (MEOHP), and mono(2-ethyl-5-carboxypentyl) phthalate (MECPP) with analytic chemistry methods (Silva et al.