The influence of enantioselectivity of the vesamicol analogs FEOBV (2) , MIBT
(8) , FBT (9) , oIV (10) , OMV (11) , OIDV (13) , FBBV (18) , 19 , TZ659 (20) , VAT (21) , and 22  on the binding affinity for VAChT, [[sigma].sub.1], and [[sigma].sub.2] receptors was reported.
Minocycline-induced black thyroid (MIBT) is a rare condition that was first described in 1967 by Benitz et al.
Pathologic examination of a MIBT reveals characteristic gross features, including the eponymous charcoal black coloring in a full-thickness distribution from the capsular layer throughout the entire thyroid parenchyma.
The nature of the black pigment in MIBT remains debated.
Clinically, MIBT has long been thought to be a harmless phenomenon without clinical ramifications.