MIC-1


Also found in: Encyclopedia, Wikipedia.
AcronymDefinition
MIC-1Macrophage Inhibitory Cytokine (genes)
References in periodicals archive ?
The absorbance value is positively correlated with the MIC-1 level in serum and standard samples, and the MIC-1 concentration in the samples was obtained through the use of standard dose-response curve.
The data for serum MIC-1 levels and age were shown as mean [+ or -] standard deviation (SD).
This study showed that the overall mean serum MIC-1 level of patients with early-stage NSCLC was 1325 [+ or -] 848 pg/ml, which was significantly higher than those of BPD patients (848 [+ or -] 183 pg/ml; t = 7.164, P < 0.001) and healthy controls (367 [+ or -] 207 pg/ml; t = 10.481, P < 0.001).
The studies involved 152 early-stage NSCLC patients and 105 healthy controls to evaluate the diagnostic accuracy of MIC-1. The ROC analyses yielded an area under curve (AUC) value of 0.90 (95% confidence interval [ CI ]= 0.80–0.94) [Figure 1].
In early-stage NSCLC patients, serum levels of MIC-1 were correlated with age ( P = 0.001), gender ( P = 0.030), and early postoperative death (within 3 years) ( P = 0.042) [Table 1].{Table 1}
Additionally, data from receiver operating characteristic (ROC) curve analysis demonstrated that serum MIC-1 had a superior performance to CA19.9 in differentiating early-stage PDAC from normal serum with a higher sensitivity (62.5% vs.
"This suggests that the MIC-1 protein produced and secreted by these tumours might be performing an important role in the development of melanoma by controlling a key process outside of the tumour," said Robertson.
By targeting MIC-1, protein levels dropped 300 to 400 percent in animal and human tissue samples, preventing blood vessel formation and decreasing tumor development by about 300 percent.
"Therapies removing MIC-1 from the blood of patients could be used to prevent tumor vessel development and as a result, the tumors would not be able to get bigger because of a lack of needed nutrition and removal of toxic cell waste products.
In the body, MIC-1 is thought to help regulate the activation of macrophages, large white blood cells that ingest foreign invaders.