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MIC90Minimum Inhibitory Concentration required to inhibit the growth of 90% of organisms
MIC90Minimum Inhibitory Concentration of Imipenem for 90%
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In this study, all EEP showed an antimicrobial effect against Staphylococcus spp isolates, MIC90 = 60 - 30 mg/mL, irrespectively of microbial resistance of the isolates.
The MIC at which 50% and 90% of the isolates were inhibited (MIC50 and MIC90 respectively) was determined for each year (Table 2).
Ceftaroline's MIC90 of 1 mg/L against these isolates was the most favorable of the 10 drugs tested.
The MIC at which 90% of the strains tested were inhibited (MIC90) from these samples was compared with MIC90 values previously reported from travelers to the same regions in 1997 (Antimicrob.
The MIC90 is the minimum inhibitory concentration of the drug that is required to decrease growth of 90% of the pathogen.
In contrast, antibiotics that rely on time-dependent killing, such as [beta]-1actams, macrolides, azalides, tetracyclines, and some others, require extended durations of concentrations above the MIC90 of the bacterial pathogen(s).
The highest MIC90 for Pseudomonas sp were observed with cefotaxime, ceftriaxone, ampicylim, cefoxitin, cefazolin, cefuroxime cephalotin, vancomycin, ampicylim/sulbactam and amoxicillin/ clavulanic acid.
Study conclusions: On a MIC90 (Minimum Inhibitory Concentration required to inhibit the growth of 90% of organisms) basis, dalbavancin was more potent than vancomycin, linezolid or daptomycin for every organism group studied.
The MIC90 of ceftazidime against 50 isolates of Acinetobacter baumannii was >128 mg/L whether avibactam was present or not, which is consistent with this species not being listed on the drug label.