(5) To [epsilon] and MinP
, if there exist a object o (o [member of] D), p and q can get "direct density reachable" from o, p and q are density connected.
After adjustment for covariates, neither MEP, MiNP
, MnBP, MBzP, nor DiNP was associated with ADHD in Bayesian multivariable adjusted models, which included adjustment for phthalate coexposures (Table 3, Figure 1; see also Table S1).
Assim como e importante conhecer a prevalencia de MINP
e tambem relevante analisar o perfil farmacoterapico dos MINPI utilizados.
Since there are interrelations and interactions among these sub-problems, the CSNDP can be formulated as a mixed integer non-linear programming problem (MINP
) at three stages, based respectively on the Knapsack Problem (KP), Salesman Travelling Problem (STP) along with the Operation Problem (OP) and Container Configuration Problem (CCP).
Urine samples were analyzed for total content (free and conjugated) of 12 phthalate metabolites: monoethyl phthalate (MEP), mono-n-butyl phthalate (MnBP), monoiso-butyl phthalate (MiBP), monobenzyl phthalate (MBzP), MEHP, MEHHP, MEOHP, mono(2-ethyl-5-carboxypentyl) phthalate (MECPP), mono-iso-nonyl phthalate (MiNP
), mono-hydroxy-iso-nonyl phthalate (MHiNP), mono-oxo-iso-nonyl phthalate (MHiOP) and mono-carboxyiso-octyl phthalate (MCiOP) by liquid chromatography-tandem mass spectrometry (LC-MS/MS) with preceding enzymatic deconjugation followed by solid phase extraction.
The total (sum of free and conjugated) content of monoethyl phthalate (mEp), monoisobutyl phthalate (MiBP), mono-w-butyl phthalate (MnBP), monobenzyl phthalate (MBzP), mono(2-ethylhexyl) phthalate (MEHP), mono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP), mono(2-ethyl5-oxohexyl) phthalate (MEOHP), mono(2-ethyl-5-carboxypentyl) phthalate (MECPP), monoisononyl phthalate (MiNP
), mono(hydroxyisononyl) phthalate (MHiNP), mono(oxoisononyl) phthalate (MOiNP), and mono(carboxyisooctyl) phthalate (MCiOP) was analyzed by isotope dilution liquid chromatography tandem mass spectrometry with preceding enzymatic deconjugation followed by automatic solid phase extraction.
The interday assay variation, expressed as the RSD, was < 20% for all analytes except MCPP (mono-3-carboxypropyl phthalate; 22%) and MiNP
(mono-isononyl phthalate; 26%).
All the HMW phthalate metabolites, except mono-isononyl phthalate (MiNP
), mono-cyclohexyl phthalate (MCHP), and mono-n-octyl phthalate (MOP) were detectable in the majority of samples.
The proportions of DEHP and DiNP excreted as their respective primary metabolites [mono(2-ethylhexyl) phthalate (MEHP) and mono-isononyl phthalate (MiNP
)] were calculated and expressed as percentages (%MEHP and %MiNP, respectively).
Suspected metabolites include mono-benzyl phthalate (MBzP), mono-ethyl phthalate (MEP), mono-isononyl phthalate (MiNP
), mono-methyl phthalate, and mono-butyl phthalate (MBP).