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MLK3Mixed Lineage Kinase 3
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MLK3 promotes metabolic dysfunction induced by saturated fatty acid-enriched diet.
34) In this study, the eup-regulation of MEKK1, ASK1, MLK2, MLK3, NIK, MEK4 and MEK7 was observed, which may be related to the activation of JNK signaling pathway.
Small G-proteins Rac1 and cdc42 activate ASK1, MLK3, and MLK3 that directly activate MKK3 and MKK6 which phosphorylates p38 on both tyrosine and threonine residue resulting in the activation of p38 pathway [68, 69].