In contrast to MA, malignant mullerian mixed tumours (MMMT
) typically have a high grade mesenchymal component and an invasive carcinomatous component.
also termed as carcinosarcoma is a highly malignant neoplasm, exhibiting malignant epithelial and stromal components.
In this paper, we report two cases of MMMT in patients with breast cancer, who had received tamoxifen.
The only documented etiologic factor in 10% to 25% of MMMT is prior pelvic radiation therapy, which is often administered for benign uterine bleeding that began 5 to 25 years earlier.
Diagnostic dilemma in a case of MMMT
of the cervix.
Moreover, recognition of this corded and hyalinized pattern of high-grade carcinoma, as distinct from both the high-grade undifferentiated spindle cells that warrant a diagnosis of MMMT
and from the low-grade epithelial cells of serous neoplasm of low malignant potential and low-grade serous carcinoma, is important for clinical management.
In addition, MMMT
is an important differential diagnostic consideration.
One case of MMMT
presented with simultaneous occurrence of uterine and ovarian malignancy, making it FIGO stage III.
MATERIAL: We here share our experience regarding three patients of MMMT encountered in 1yr between October 2008 to October 2009 at the Gynae and Obst Dept, Medical College Kolkata.
MMMT is a very aggressive disease with extremely poor prognosis.
INTRODUCTION: Uterine malignant mixed mullerian tumor(MMMT
) is an uncommon carcinosarcomatous neoplasm with a highly malignant, biphasic pattern consisting of both epithelial and mesenchymal components (2).
To the Editor: A uterine carcinosarcoma (malignant mixed Mullerian tumor [MMMT]) is a rare, aggressive, malignant tumor which demonstrates both malignant epithelial (carcinoma) and mesenchymal (sarcoma) components. MMMTs
account for 2-5% of all uterine malignancies.