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MMP1Collagenase/Matrix Metalloproteinase-1
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In our study, we found that expression of MMP1 in A549 cells infected by PRDM14-shRNA was down-regulated significantly, while the expression of TIMP1 and TIMP2 was up-regulated significantly [Figure 4].
The aim of our research was to determine the effects of prolactin, estrogen or a combination of each on the level of the extracellular matrix proteins, matrix metalloproteinase-1 (MMP1), and transforming growth factor beta (TGF-[beta] 3), expression.
The qPCR primers and hydrolysis probes for the genes CALM2 [calmodulin 2 (phosphorylase kinase, delta)], CHPT1 (choline phosphotransferase 1), CXCL13 [chemokine (C-X-Cmotif) ligand 13], ERBB2 [v-erbb2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)], ESR1 (estrogen receptor 1), IGKC (immunoglobulin kappa constant), MLPH (melanophilin), MMP1 [matrix metallopeptidase 1 (interstitial collagenase)], OAZ1 (ornithine decarboxylase antizyme 1), PGR (progesterone receptor), RAC-GAP1 (Rac GTPase activating protein 1), RPL37A, TOP2A [topoisomerase (DNA) II alpha 170kDa], and UBE2C (ubiquitin-conjugating enzyme E2C) were identified with Primer Express[TM] software (Applied Biosystems) according to the manufacturer's instructions.
A number of these genes detected by the microarray as significantly induced in lymphocytes, such as IL1[beta], IL6, CCL2/MCP1, CXCL1/GRO1, chemokine C-X-C motif ligand 2/growth-related oncogene beta (CXCL2/GRO2), CD14 antigen (CD14), and interstitial collagenase matrix metalloproteinase 1 (MMP1), were selected for a confirmation test using a real-time reverse-transcriptase-polymerase chain reaction method.
A Taiwanese group composed another panel with 4 proteins (MMP1, KNG1, ANXA2, and HSPA5) that able to diagnose OSCC and also to predict OPMDs malignant transformation [157].
Mehta, "Anoxia-reoxygenation stimulates collagen type-1 and MMP1 expression in cardiac fibroblasts: modulation by the PPAR-y ligand pioglitazone," Journal of Cardiovascular Pharmacology, vol.
The data from RNA-Seq were confirmed by qRT-PCR resulting in a 32.5-fold increase of SAA1 mRNA (p = 0.003), 7.8-fold increase of MMP13 mRNA (p = 0.001), 4.2-fold increase of MMP1 mRNA (p = 0.03), 7.5-fold increase of MMP3 mRNA (p = 0.003), and 20.2-fold increase of IL6 mRNA (p = 0.04) (Table 2; Figure 4(c)).
In contrast, the incubation with IFN-[gamma]/LPS stimulated the production of a wide assortment of MMPs (MMP1, MMP2, MMP7, MMP8, MMP10, and MMP13), but did not affect MMP12 secretion (Figure 5(b)).
Recent studies showed that adiponectin might also contribute to synovitis and joint destruction in RA by stimulating MMP1 and MMP-13 [105].
Cell viability, matrix metalloproteinase 1 (MMP1), pro-collagen 1, cellular and nuclear morphology, cell cycle, intracellular reactive oxygen species (ROS), caspase 3 and hyaluronidase inhibition assays were performed.
(2-4) Secreted-type MMPs can be classified into 6 subgroups according to their substrate specificity and structural differences (2): (1) collagenases, including tissue collagenase (MMP1), neutrophil collagenase (MMP8), and collagenase 3 (MMP13); (2) gelatinases, such as gelatinase A (MMP2) and gelatinase B (MMP9); (3) stromelysins, including stromelysin 1 (MMP3) and stromelysin 2 (MMP-10); (4) matrilysins, such as matrilysin 1 (MMP7) and matrilysin 2 (MMP26); (5) furin-activated MMPs, including stromelysin 3 (MMP-13) and epilysin (MMP 28); and (6) other MMPs such as metalloelastase (MMP12), MMP19, enamelysin (MMP-20), MMP21, and MMP-27.
The promoter region of inducible MMP genes (i.e., MMP1 and MMP3) shows remarkable conservation of regulatory elements, and their expression is induced by growth factors, cytokines, and other environmental factors, such as contact with extracellular matrix (7-9).