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(2016) MMP3 and TIMP2 gene variants as predisposing factors for Achilles tendon pathologies: Attempted replication study in a British case-control cohort.
Based on univariate analyses, Group A had a significantly younger age (p<0.001), female sex (p=0.039), lower serum MMP3 (p=0.021), lower HAQ-DI (p=0.015), lower HAM-D score (p=0.018), and a higher Role/Social component summary score (RCS) in the SF-36 (p=0.009) compared to Group B.
After SDS-PAGE, equal amounts (30 [micro]g) of cell extracts were transferred onto polyvinylidene fluoride membranes (Bio-Rad, Hercules, CA, USA), followed by incubation with primary rabbit monoclonal antibodies against aldehyde-3-dehydrogenase (ALDH); matrix metalloproteinase (MMP) 1, MMP2, MMP3, and MMP9; collagen I, II, III, IV, and V; and fibronectin.
MMP2 (rs243865, rs2285053, rs243847, (2012) (20) rs2287074, rs9923304, rs11639960) MMP3 (rs639752, rs650108, rs679620, rs522616) MMP9 (rs3918253, rs17576, rs17577) MMP13 (rs2252070) MMP14 (rs1042704) TIMP2 (rs9894526) Salazar-Pelaez et al.
The aim of the present study was to determine whether the most common MMP1, MMP2, MMP3, and MMP9 gene polymorphisms in maternal and fetal genes are associated with preeclampsia.
Considering this patient's joint manifestations, the change in ultrasonography findings, and the time course of the ESR and MMP3 levels, adalimumab apparently contributed to the subsidence of the refractory arthritis and the discontinuation of PSL in this adolescent girl.
As other targets, mRNA from TLR is regulated by miRNAs, and miR-19a and miR-19b were demonstrated to upregulate TLR-2 expression in RASF; even more, downregulation of miR-19b in activated RASF was associated with an increased production in IL-6 and MMP3 release, so they seem to work as negative regulators of inflammatory responses .
En experimentos realizados se demostro que MMP3 induce la expresion de Rac1, lo que a la vez incrementa la produccion de especies reactivas de oxigeno (ROS) y Snail1 [34, 35].
Positive selection on MMP3 regulation has shaped heart disease risk.
In situ gene expression and localization of MMP1, MMP2, MMP3, MMP9 and their inhibitors TIMP1 and TIMP2 in human renal cel carcinoma.
MMP3 activity was estimated with casein zymography (A) Coomassie blue-stained polyacrylamide gel of casein zymography; (B) relative intensity of bands.
Additionally, degeneration of the ECM is accelerated due, in part, to the increased expression of metalloproteinases (MMPs), mainly MMP-1 and MMP3 .
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