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in 1992 when the mouse mammary tumor virus (MMTV) was inserted to modify the expression of the Notch-4 genes.
Lack of cross-reactivity of primers from 5 BLV genome regions with representatives of mammalian and avian retrovirus subfamilies and human exogenous and endogenous viruses previously identified in human breast tissue * Nested liquid-phase PCR for BLV genome regions Virus Subfamily Cell line harboring virus LTR gag (source ([dagger])) RSV Alpharetrovirus XC, rat cell line, - transformed with RSV (CCL/NBRL) MSV Alpharetrovirus F81, cat cell line, MSV - - infected (CCL/NBRL) MMTV Betaretrovirus GR, mouse mammary tumor - - cell line (G.
CHO-K1 cells were stably transfected using the AR and the luciferase reporter gene regulated by the hormone response element (HRE) present in themousemammary tumor virus (MMTV) promoter.The system has a high sensitivity (0.1 nmol/L) for androgens such as testosterone and can distinguish androgenic and antiandrogenic activities.
Lee et al., "The role of lipid peroxidation products and oxidative stress in activation of the canonical wingless-type MMTV integration site (WNT) pathway in a rat model of diabetic retinopathy," Diabetologia, vol.
Abbreviations aP2: Adipocyte protein 2 [beta]-Catenin: Beta-cadherin associated protein C/EBP[alpha]: CCAAT/enhancer binding protein alpha CoPP: Cobalt protoporphyrin IX dichloride FAS: Fatty acid synthase GLUT5: Glucose transporter member 5 HO: Heme oxygenase HO-1: Heme oxygenase isozyme 1, inducible form HO-2: Heme oxygenase isozyme 2, constitutive form MSC: Mesenchymal stem cell NADPH: Nicotinamide adenine dinucleotide phosphate (reduced form) Peg-1/Mest: Paternally expressed gene 1/mesoderm specific transcript PPAR[gamma]: Peroxisome proliferator activated receptor gamma ROS: Reactive oxygen species SnMP: Tin mesoporphyrin IX dichloride TNF[alpha]: Tumor necrosis factor-alpha Wnt10b: Wingless-type MMTV integration site family, member 10b.
The mouse mammary tumor virus (MMTV) is known to cause mammary carcinoma in C3H and Strong A strains of mice.
This consideration pushed some authors to try to resolve the dilemma, through a genome-wide association meta-analysis  showing three well-identified genes, which, if mutated by SNPs, seems to be associated with endometriosis: WNT4 encodes for wingless-type MMTV integration site family, member 4, and is important for the development of the female reproductive tract  and steroidogenesis ; VEZT encodes vezatin, an adherens junction transmembrane protein that is down regulated in gastric cancer ; GREB1 encodes growth regulation by estrogen in breast cancer 1, an early response gene in the estrogen regulation pathway involved in hormone dependent breast cancer cell growth .For an accurate overview of the genetic variants reported in this chapter, refer to Table 1.
The mouse version, known as mouse mammary tumor virus, or MMTV, is passed from mother to offspring through breast milk.
El efecto de las hormonas sobre la replicacion de los retrovirus comenzo a despertar gran interes desde el descubrimiento de la estimulacion por glucocorticoides de la replicacion y liberacion del virus del tumor mamario de raton (MMTV) describiendose un elemento de respuesta hormonal en el genoma del virus que se pudo situar en la region LTR (Smoller et al, 1961).
Functional ROR1 ligands have remained unknown, though secreted proteins of the wingless-type MMTV integration site(Wnt) family have recently been proposed as ligand candidates (3), (4) and Wnt5a was shown to bind Rorl (5).Ten years after identification of ROR1 (1), gene expression profiling of B cell malignancies on a genomic scale displayed RORI overexpression in leukemic B cells of Chronic Lymphocytic Leukemia (CLL) (6), (7)
Abbreviations: ATM; Annual mean temperature variability, MMTV; Monsoon mean temperature variability, WMTV; winter mean temperature variability, PMMTV; Pre-monsoon mean temperature variability, PoMMTV; Post monsoon mean temperature variability,
A headline on MMTV asserts that "O'Reilly Supports Rep King's Islamic Extremism Hearings: 'You've Got to Get a Handle on It'." The language of Islamic extremist has infected the US congress.
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