MNBNMicronucleated Binucleated (cells)
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The new MNBN commander looked to the future with confidence:
MNBN will then be augmented by the 'Over the Horizon Reserve Forces' and cooperate closely with BiH local authorities to practice required skills for large scale peace support operations, EUFOR announced.
One-unit increases in the expression of 7 of the 36 genes evaluated (PDCD11, LATS2, TRIM13, CD28, SMC1A, IL7R, and NIPBL) were associated with significantly lower MNBN frequencies, with MR ranging from 0.81 (95% CI: 0.88, 0.96) for PDCD11 to 0.64 (95% CI: 0.77, 0.97) for NIPBL (Figure 1A).
Six of the seven genes whose expression was associated with significantly lower MNBN frequency (i.e., all except TRIM13; Figure 1A) were significantly associated with the highest versus lowest category of at least one exposure biomarker ([M.sub.1]dG, DR CALUX[R], ER[alpha] CALUX[R], or AR CALUX[R]; Figure 1B).
None of the GWAS SNPs were significant predictors of MNBN frequencies (see Supplemental Material, Figure S3).
SNPs in EPHX1, EPHX2, and CYP2E1 were significantly associated (unadjusted overall p-value < 0.05) with the frequency of MNBN lymphocytes (Table 4).
This suggests that the fetus may be exposed to carcinogenic chemicals in utero via the placenta, and that such exposures may be sufficient to exert early biological effects manifested as an increase in the frequency of MNBN, a marker that has been associated with cancer risk in adults (Bonassi et al.
In the total population (Table 2), median MNBN frequencies were significantly higher in mothers (2.36 per 1,000 BN cells) than in newborns (1.53 per 1,000; p < 0.001, Mann--Whitney).
None of the variables included in the initial model (maternal age, birth weight, child sex, maternal BMI, GA, delivery type, preterm status, smoking, and supplement intake) were significant predictors of MNBN and CBPI among the 173 children with complete data for all potential predictors (Table 3).
As for all births combined, no variables significantly predicted MNBN frequency or CBPI (Table 3).
Next, we performed multivariable regression analysis for the full-term infants with paired samples from their mothers to estimate associations with maternal genotoxicity parameters (MNBN, MNMONO, and CBPI) in addition to the variables evaluated previously (data not shown).
In the total population (n = 163), mothers delivering a girl had significantly fewer MNBN than did those delivering a boy.