BPA was obtained from TCI Europe (Zwijndrecht, Belgium), while MiBP, MnBP
, and MEHP were from Orchid Cellmark (New Westminster, BC, Canada).
Se calculo la biomasa de las distintas presas consumidas por los zorros en el MNBP
reanalizando los datos de la dieta, obtenida a partir del analisis de los restos presentes en excrementos de zorros colorados y grises, de Zapata et al.
Douching in the past month was associated with higher concentrations of MEP but not MnBP
. No other feminine-hygiene product was significantly associated with either MEP or MnBP
We observed no notable effect modification by child sex, with the possible exception of MnBP
The following 11 phthalate metabolites were measured: mono-ethyl phthalate (MEP), mono-iso-butyl phthalate (MiBP), mono-n-butyl phthalate (MnBP
), 3OH-mono-n-butyl phthalate (OH-MnBP), mono-benzyl phthalate (MBzP), mono-(2-ethylhexyl) phthalate (MEHP), mono-(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP), mono-(2-ethyl-5-oxohexyl) phthalate (MEOHP), mono-hydroxy-iso-nonyl phthalate (MHiNP), mono-oxo-isononyl phthalate (MOiNP), and mono-n-octyl phthalate (MOP).
Upon arrival at the CDC, the samples were processed, aliquoted, and stored at or below -20[degrees] C until analysis to measure concentrations of creatinine and, using online solid-phase extraction followed by high-performance liquid chromatography-electrospray ionization-isotope-dilution tandem mass spectrometry, of nine phthalate metabolites in both batches: MEP, mono-N-butyl phthalate (MnBP
), MiBP, MCPP, MBzP, MEHP, MEOHP, MEHHP, and MECPP; and three additional metabolites in the second batch: MCOP, monocarboxy-isononyl phthalate (MCNP), and cyclohexane-1,2-dicarboxylic acid mono(hydroxy-isononyl) ester (MHINCH).
Only one cross-sectional study has investigated associations of several phthalates and pulmonary function, reporting deleterious associations of spirometric measurements with MCPP, mono-n-butyl phthalate (MnBP
), and DEHP metabolites (Cakmak et al.
We quantified urine concentrations of monoethyl phthalate (MEP), mono-n-butyl phthalate (MnBP
), mono-isobutyl phthalate (MiBP), mono(3-carboxypropyl) phthalate (MCPP), monobenzyl phthalate (MBzP), and four metabolites of DEHP: mono(2-ethylhexyl) phthalate (MEHP), mono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP), mono(2-ethyl-5-oxohexyl) phthalate (MEOHP), and mono(2-ethyl-5-carboxypentyl) phthalate (MECPP) with analytic chemistry methods (Silva et al.
To explore to which extent associations could be confounded by exposure to other phenols or phthalates, we ran analyses simultaneously adjusted for all phenols (BPA, benzophenone-3, triclosan, [SIGMA]dichlorophenols, [SIGMA]parabens), and phthalate metabolites [monoethyl phthalate (MEP), mono-n-butyl phthalate (MnBP
), mono-isobutyl phthalate (MiBP), monobenzyl phthalate (MBzP), monocarboxyoctyl phthalate (MCOP), mono(3-carboxypropyl) phthalate (MCPP), monocarboxynonyl phthalate (MCNP), and [SIGMA]DEHP] concentrations.
We considered including monon-butyl phthalate (MnBP
; a metabolite of DnBP), but because DnBP is infrequently used in PCPs (FDA 2014b), it was not a focus of our analysis.
We modeled exposure based on the distribution of third trimester maternal urinary mono-n-butyl phthalate (MnBP
) concentrations observed in the Mount Sinai Children's Environmental Health Center Study.