MNGCMulti-Nucleated Giant Cells
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AA has been reported to induce MNGC formation in testis (8,14,17,19,22), coinciding with our results.
Values are expressed as median (Q25-Q75) and minimum-maximum values Groups (n=7) Percentages of seminiferous tubules containing multinucleated giant cells Median (Q25-Q75) Minimum value Maximum value Control No MNGC detected 0.0 0.0 L-cysteine No MNGC detected 0.0 0.0 Acrylamide 25.0 (0.0-40.0) (a) 0.0 75.0 Acrylamide+ L-cysteine 0.0 (0.0-0.0) 0.0 10.0 (a): p<0.001 when compared with the acrylamide+L-cysteine group; MNGC: multinucleated giant cells TABLE 4.
On the other hand, this compound increases vacuolization, DNA damage, the number of multinucleated giant cells (MNGCs) (6), cell cycle delay (7), and the number of morphologically abnormal sperms and apoptotic cells (8).
MNGCs were not observed in the control and L-cys groups.
In AA-treated group, numerous MNGCs were observed in the STs, whereas the interstitial fields and other structures appeared normal (Figure 2c, 3a, 3b).
The percentages of STs containing MNGCs in AA and AA+L-cys-treated groups were compared.
Notably, the STs that contained MNGCs displayed less PCNA positivity than the tubules without MNGCs.
In addition, we observed several MNGCs in the AA alone group and another few in the AA+L-cys-treated group.
showed that MNGCs express some markers which are also expressed by osteoclasts, like tartrate-resistant acid phosphatase (TRAP) and vitronectin receptor (VNR) [29].