But, in boys, systolic blood pressure and mean arterial pressure were found to be significantly higher in the MPAG
as compared to LPAG despite insignificant differences in the body composition (Table 2).
, AcMPAG, and the carboxybutoxy ether of MPA (MPAC) were kind gifts from Roche Pharmaceuticals.
2]O), polystyrene (Elvetec), or polypropylene (Sarstedt) tubes to obtain MPA and MPAG
concentrations of 0.
Several HPLC-tandem mass spectrometry (MS/MS) methods for monitoring MPA, free MPA, and MPAG
in serum or plasma have been reported.
Coelution of MPAG
or AcMPAG with MPA would therefore give falsely increased MPA concentrations.
The uremic state itself decreases MPA protein binding, which is also achieved by competition with the retained MPAG
was isolated in our laboratory from the urine of transplant patients.
Plasma concentrations of MPAG
exceed MPA concentrations in all transplant patients who receive MMF, and reach values >100-fold higher in renally impaired patients (3).
Most studies on the pharmacokinetics of MPA have utilized HPLC procedures (6, 7) to measure both MPA and MPAG
During MMF therapy, MPAG
peak concentrations observed in plasma of patients (5-600 mg/L) can be up to 300-fold higher than those of MPA (0.
To date, only two methods allow the simultaneous measurement of MPA and MPAG
is commonly measured in PK studies, no studies have shown that its concentration relates to either toxicity or acute rejection.