Subjects with confirmed recent submassive PE (symptoms onset <15 days), significant perfusion defects, mPAP
[greater than or equal to]50 mm Hg revealed by ECHO, and with no contraindication for thrombolytic agent were given thrombolytic therapy.
Mean pulmonary artery pressure (MPAP
) was calculated by the following formula MPAP
= 0.61 x PASP + 2 mm Hg and patient was labelled as having PAH if MPAP
[greater than or equal to]25mmHg.
Right atrial pressure, right ventricular pressure, pulmonary artery pressure including PASP, mean pulmonary artery pressure (mPAP
), diastolic pulmonary arterial pressure (DPAP), and pulmonary artery wedge pressure (PAWP) were measured by RHC using a 6-lumen Edward catheter.
Swan Ganz parameters POD 0 POD 1 POD 13 POD 20 CVP 13 8 11 14 (mm Hg) PASP 139 110 114 89 (mm Hg) PADP 85 60 59 41 (mm Hg) mPAP
103 79 77 60 (mm Hg) CO -- 4.9 7.1 6.4 (l/min) CI -- 3.2 4.5 4.1 (l/m/m2) CVP = central venous pressure, PASP = pulmonary artery systolic pressure, PADP = pulmonary artery diastolic pressure, mPAP
= mean pulmonary artery pressure, CO = cardiac output, CI = cardiac index, SVR = systemic venous resistance, and Sv[O.sub.2] = systemic venous oxygen saturation.
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of 12-week-old rats was determined in order to examine the effect of IUGR on hemodynamics.
The diagnostic criteria of PH, PAH, and CTEPH were in accordance with the following 2015 European Society of Cardiology/European Respiratory Society guidelines:[sup](1) resting mean PAP (mPAP
) measured through right cardiac catheterization ≥25 mmHg (1 mmHg = 0.133 kPa), and (2) pulmonary artery wedge pressure (PAWP) ≤15 mmHg.
APTT: Activated partial thromboplastin time BMI: Body mass index CVD-ILD: Collagen vascular disease-associated interstitial lung disease D-ILD: Drug-induced interstitial lung disease DLCO: Diffusion capacity for carbon monoxide DPLD: Diffuse parenchymal lung disease FVC: Forced vital capacity HP: Hypersensitivity pneumonitis HRCT: High resolution computed tomography ICU: Intensive care unit INR: Prothrombin time international normalized ratio IPF: Idiopathic pulmonary fibrosis MDD: Multidisciplinary discussion mPAP
: Mean pulmonary artery pressure NSIP: Nonspecific interstitial pneumonia SLB: Surgical lung biopsy TBLC: Transbronchial lung cryobiopsy UIP: Usual interstitial pneumonia VATS: Video-assisted thoracoscopic surgery.
The hemodynamic measurements included mean right atrial pressure (RAP), mean pulmonary pressure (mPAP
), pulmonary capillary wedge pressure (PCWP), pulmonary vascular resistance (PVR), and cardiac index (CI, thermodilution or Fick method, as appropriate).
Demographics, functional class, clinical history of ILD, chest computed tomography, pulmonary function test (PFT), ECHO results including RV size, function, RV systolic pressure (RVSP), mean pulmonary arterial pressure (MPAP
), tricuspid annular plane systolic excursion (TAPSE), and RV index of myocardial performance (RIMP) were examined.
The minimum sPAP for the diagnosis of PH in such studies was [greater than or equal to] 30 mmHg for echoderived measurements, sPAP [greater than or equal to] 30mm Hg or mPAP
[greater than or equal to] 20 mm Hg for RHC-derived measurements.