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Molecular studies of MPBC to date have predominantly used IHC, fluorescence in situ hybridization, and mRNA transcriptional profiling techniques and have demonstrated that MPBC clusters with the TNBC/basaloid phenotypes.
Given the histologic picture of MPBC with various types of mesenchymal differentiation, including the spindle cell (sarcomatoid) and chondroid variants of the disease, there has been significant interest in studying genes and biologic pathways associated with the epithelial to mesenchymal transition and the cancer stem cell hypothesis (32-37) in MPBC.
The disease-free and overall survival results for patients with MPBC is significantly shorter than that for non-MPBC treated with cytotoxic agents in either the metastatic or the neoadjuvant settings.