* Three-dimensional Magnetization Prepared Rapid Gradient Echo T1W (3D MPRAGE
) sequence in sagittal plane (TR 1900 ms, TE 2.26 ms, spatial resolution 0.9x07x0.9 mm, field of view(FOV) 250 mm, matrix 256x256);
MR sequences used were 2D fast spin echo T2 (FSE T2) for 4 patients, 3D FSE T2 for 2 patients, Spin echo T1 (SE T1) for 2 patients, and magnetization prepared rapid acquisition gradient echo T1 (MPRAGE
T1) for all 8 patients.
A standard conventional MR imaging protocol included axial and sagittal T2-weighted turbo spin-echo (TSE) (TR/TE = 5000/100 ms, slice thickness (thk): 5 mm), axial fluid-attenuated inversion recovery (FLAIR) (TR/TE = 6000/120 ms, IR: 2000 ms, thk: 2 mm) sequence, and a T1-weighted 3D magnetization prepared rapid acquisition gradient-echo sequence (MPRAGE
) (TR = 72/TE = 3,2 ms, NSA = 1, FOV = 256 mm, slice thk: 1 mm, gap = 0 mm, flip angle = 8[degrees], matrix = 256 x 256 pixels) through 160 slices of the entire brain.
Narayana, "3D MPRAGE
improves classification of cortical lesions in multiple sclerosis," Multiple Sclerosis, vol.
A sagittal T1-weighted 3D MPRAGE
image was acquired, followed by a DTI sequence with diffusion-weighted volumes in 12 directions and b=1000 s/m[m.sup.2].
A high-resolution structural image was obtained before the two functional runs using a 3D T1-weighted imaging sequence using an MPRAGE
(TFE) sequence (TR = 2300 ms; TE = 2.98 ms; 192 slices; matrix = 256 x 256 mm; voxel size =1 x 1 x 1 mm; and FOV = 256mm).
We used a 1.5 T MRI unit, but we were not able to use more detailed and advanced brain imaging methods such as MPRAGE
or brain segmentation.
Our preliminary study using 3.0 T T1-weighted NMR and 3D MPRAGE
scanning showed a linear relationship between signal strength (DSI) and Gd-DTPA concentration (11).
Each subject's anatomical image was acquired using a high-resolution (1x1x1 [mm.sup.3]), T1-weighted, 3D gradient-echo pulse sequence (MPRAGE
; TR/TE/TI = 1770 ms/2.93ms/900 ms).
T1 weighted MPRAGE
or SPGR images; 1.5mm slice thickness are acquired as a 3 dimensional (3D) volume, thereby post processing and reformatting images into multiple planes.
The following sequences were obtained: (1) sagittal magnetization prepared rapid gradient echo (MPRAGE
; TR/TE: 2530 ms/3.39 ms; 1 acquisition; Flip: 7 degrees, inversion time: 1100 ms; FOV: 22 cm; acceleration: 2; voxel (mm): 1 x 1 x 1); (2) axial FSE T2-weighted images (TR/TE: 11,730 ms/89 ms; 2 acquisitions; Flip: 120 degrees; FOV: 22 cm; acceleration: 2; voxel (mm): 0.6 x 0.4 x 2.5); (3) axial FLAIR (TR/TE: 9,000 ms/137 ms; 1 acquisition; Flip: 150 degrees; FOV: 22 cm; voxel (mm): 0.7 x 0.7 x 4); (4) axial single-shot EPI DTI (TR/TE (ms): 7000/142; Flip: 90 degrees; 1 acquisition; voxel (mm): 2 x 2 x 2).
Structural MRI scanning was performed using the Siemens 3.0 T Trio Tim using the MPRAGE