MPXRMouse Pregnane X Receptor
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Similar to BPA, none of them activated mPXR (Figure 4C).
Because BPA and certain structural analogues are selective agonists for hPXR over mPXR, we used the human intestinal cell line LS 180 to test the effect of BPA and analogues on PXR target genes.
We found that BPA is a potent agonist for hPXR but not for mPXR and rPXR.
In addition, chronic activation of mPXR by PCN was reported to increase atherosclerosis in apolipoprotein E-deficient mice (Zhou et al.