Also found in: Medical.
MRP2Multidrug Resistance-Associated Protein 2
MRP2Multidrug Resistance Protein-2
References in periodicals archive ?
RE, CA, and CL Increased Expression of Sestrin2 and MRP2 Concomitantly with Enhanced Nrf2 mRNA and Protein Levels in HepG2 Cells.
Arsenic induces expression of the multidrug resistance-associated protein 2 (MRP2) gene in primary rat and human hepatocytes.
Jeffery, "Sulforaphane and erucin increase MRP1 and MRP2 in human carcinoma cell lines," The Journal of Nutritional Biochemistry, vol.
Although numerous MDR genes are found, such as MDR associated protein (MRP1), MRP2, MRP3, MRP5, major vault protein (MVP), glutathione S-transferase [pi] (GST-[pi]) (Huang et al.
The canalicular membrane contains a bile salt export pump (BSEP) for monovalent bile salts, a conjugate export pump (MRP2) for divalent bile salts, and various other amphipathic conjugates (Saito et al.
MRP2, MRP4 and MRP5 are expressed in all cell variants, but the expression levels are differently distributed.
Thiolated PAs on Mrp2 efflux protein pump showed inhibitory efficiency depending on their molar mass and extent of thiolation.
galloprovincialis mrp1 and mrp2 (Mg mrp1 and Mg mrp2), genes involved in the detoxification of okadaic acid in M.
Genistein's reported effects include the ability to inhibit multidrug resistance protein 2 (MRP2) efflux function, breast cancer resistance protein (BCRP), and P-gp.
The work horses for detoxification are 1) MRP1, the transmembrane transporter serving most cells in the body for exporting toxins to circulation, 2) OATP, the basolateral membrane transporter which moves toxin conjugates from the blood into the hepatocytes or renal tubule epithelial cells, and 3) MRP2, the apical transporter that moves toxin conjugates (and some bile salts) into the bile canaliculus or renal proximal tubule lumen.
Involvement of other uptake transporters (e.g., OATP2B1, OATP1A2, OAT2, and OAT7) and apical transporters (such as MATE1, MRP2, BCRP, and MDR1/3) could not be excluded.