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MRP3Multidrug Resistance Protein 3
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(55) BSEP and MRP2 are from the same superfamily of transporters known as ATP-binding cassette (ABC) transporters, which also includes the Phase III transporters MRP1, MRP3, MRP4, BCRP, and P-gp.
Thus, during cholestasis, MRP3, MRP4, and OST[alpha]-OST[beta] may provide effective protection against hepatocellular BS overload.
Maher et al., "Induction of Mrp3 and Mrp4 transporters during acetaminophen hepatotoxicity is dependent on Nrf2," Toxicology and Applied Pharmacology, vol.
Heijn et al., "Specific detection of multidrug resistance proteins MRP1, MRP2, MRP3, MRP5, and MDR3 P-glycoprotein with a panel of monoclonal antibodies," Cancer Research, vol.
The expression of MRP3 is high in duodenum and colon, and lower in all other parts of the intestine [35].
Herndon II et al., "MRP3: a molecular target for human glioblastoma multiforme immunotherapy," BMC Cancer, vol.
However, controlled price at milling (MRP3) and different pricing mechanism (MRP5), both were loaded on fifth actor; have been removed from this factor.
While canalicular BA is exported by the bile salt export pump (BSEP) and multidrug resistance protein (MRP) 2 remains unchanged [9], the elimination of accumulating BAs from the liver is reinforced through the activation of an alternative basolateral transport system involving the organic solute transporter alpha/beta (OST[alpha]/[beta]) and MRP3 and 4 proteins [9, 10].
MRP3, BCRP, and P-glycoprotein activities are prognostic factors in adult acute myeloid leukemia.
Owing to the inhibitory effect of MK 571 on MRP3, which predominantly mediates drug efflux from the basolateral side [29, 30], the intracellular accumulation of rutin was clearly higher in the presence of 20 [micro]M MK 571 (109.61 [+ or -] 4.81 versus 175.68 [+ or -] 8.19 nmol/L x mg x protein, P < 0.05, n = 7).
For example, knocking out the gene encoding for MRP4 increases inflammatory pain threshold [45] and knocking out the gene encoding for MRP3 alters morphine pharmacokinetics [44].
MP also seemed to have an effect on the expression levels of several transporters; MDR (P-glycoprotein), cMOAT1 (MRP2) and cMOAT2 (MRP3) were upregulated, whereas the expression of the sodium/taurocholate transporter was transcriptionally repressed.