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MRP4Multidrug Resistance Protein 4
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(55) BSEP and MRP2 are from the same superfamily of transporters known as ATP-binding cassette (ABC) transporters, which also includes the Phase III transporters MRP1, MRP3, MRP4, BCRP, and P-gp.
Thus, during cholestasis, MRP3, MRP4, and OST[alpha]-OST[beta] may provide effective protection against hepatocellular BS overload.
Decouture et al., "MRP4 (ABCC4) as a potential pharmacologic target for cardiovascular disease," Pharmacological Research, vol.
Reurset al., "A role for multidrug resistance protein 4 (MRP4; ABCC4) in human dendritic cell migration," Blood, vol.
Both organic anions and xenobiotics in the blood use the same organic anion transporters (OATs) for entry into proximal tubule cells and they then exit these cells through ATP dependent ABCC2 (MRP2) and ABCC4 (MRP4), cassette transporters located at the luminal membrane of the cells (Sekine et al., 2006).
The multidrug resistance-associated protein, MRP4 is an ATP-dependent binding cassette (ABC) transporter that belongs to a family of transporters linked to the efflux of various organic anions and nucleotides.
Quantitative RT-PCR analyses revealed that EPA and/or DHA significantly downregulate the expression of genes controlling BA synthesis (CYP7A1 and CYP27) and uptake (NTCP), while genes involved in efflux (such as MRP2, MRP3, MRP4, and OST[beta]) and metabolism (SULT2A1) were upregulated (Figure 1(a)).
proved that ASA in both in vitro cell lines [11, 12] and in vivo platelets (over two months of treatment) enhances expression of the multidrug resistance protein 4 (MRP4), high concentration of which is associated with greater TxB2 synthesis, and subsequently more intense collagen-induced aggregation [13].
However, tanshinol at 1 mM did not inhibit human organic anion transporting polypeptide 4C1 (OATP 4C1), organic cation transporter 2 (OCT2), organic cation/carnitine transporter 1 (OCTN1), multidrug and toxin extrusion protein 1 (MATE1), and MATE2-K in transfected HEK293 cells or P-glycoprotein (P-gp), multidrug resistance-associated protein 2 (MRP2), MRP4, and breast cancer resistance protein (BCRP) in inside-out membrane vesicles that expressed specific transporter [7, 56].
ATP-dependent efflux transporters, multidrug resistance-associated protein 2 (Mrp2), Mrp4, and P-glycoprotein (Mdr1b) are localized in the apical membrane of renal proximal tubules and are responsible for the secretion of organic anions and cations from the proximal tubular cells into the urine [14].
DADS promoted MRP3 gene expression (p < 0.05) as well as DADS and DATS increased MRP4 and MRP6 gene expression (p < 0.05) in the colo 205 xenograft mice.