MSA-PMultiple System Atrophy Patients with Parkinsonism
References in periodicals archive ?
However, these subtypes share common histopathological changes, characterized by neuronal loss, gliosis and the presence of glial cytoplasmic inclusions (GCI) with a-synuclein.5 In MSA-P the degenerative changes predominantly affect the basal ganglia, particularly the putamen seen as hyperintense rim at the putaminal edge, atrophy and hypointensity of putaminal body on T2WI while in MSA-C changes predominantly affect infratentorial structures like pons and cerebellum, seen as atrophy and hyperintense signals in pons, cerebellum and middle cerebellar peduncles with pontine hyperintensity (hot cross bun sign) on axial image,4 which was seen in both of our patient's MRI.
This study was a retrospective study evaluating the medical records of all MSA-P patients and case-matched PD patients from September 2010 to May 2015 in Center of Parkinsonism and Movement Disorder, The Second Affiliated Hospital of Soochow University.
MSA-P group had higher AHI (1.15 [0.00, 8.73]/h vs.
As tonic chin EMG activity and AHI showed significant difference between MSA-P group and PD group, both of them had great associations with RBD, so we divided both groups into with (MSA + RBD; PD + RBD) or without RBD (MSA - RBD; PD - RBD) subgroups to make other comparisons.
[Table 4] shows that the presence of MSA-P ([sz] = 0.552, P < 0.001) and RBD ([sz] = 0.433, P < 0.001) was associated with higher tonic EMG density.{Table 4}
The main finding was that the MSA-P group had higher tonic tone than the PD group, irrespective of whether there was clinical RBD or not.
That was MSA-P group had higher tonic tone than the PD group, irrespective of whether there was clinical RBD or not.
The study showed higher tonic chin EMG density in the MSA-P group, which could be attributed to the more rapid and widespread neurodegenerative pathology in MSA-P as compared to that in PD.
We suspected that the SLD, PPN, and BG are affected earlier and more severely in MSA-P than PD, resulting in a higher REM sleep tonic chin EMG density in MSA-P.
Putaminal abnormalities may be present in MSA-P patients MRI, other findings include hypo intense sign of the putamen with marginal hyper intense sign in T2.
In a similar study, by Balas et al, (10) depression was reported as a common symptom and was statistically significant in MSA-P patients compared with controls (P = .013).
M, is another psychiatric manifestation described by Balas et al (10) and Chang et al." Balas et al (10) noted that MSA-C and MSA-P patients had significantly more state anxiety (P = .009 and P = .022, respectively) compared with controls, although Chang et al" noted higher anxiety scores in MSA-C patients compared with controls and MSA-P patients (P < .01).