In addition, in the DMCL red group, 12 genes (RUNX1, PDGFRA, EHBP1, GPC3, AXIN2, KDR, GLMN, MSMB
, EPHB2, MSR1, and KIT, Table 3) were upregulated in normal fibroblast cells.
The 32-year-old Shkreli -- who made headlines when he jacked up the price of the toxoplasmosis drug Daraprim from $13.50 to $750 -- was portfolio manager for the hedge fund MSMB
Capital Management LP from October 2009 to March 2014, and also served as portfolio manager of another hedge fund he founded and controlled, MSMB
Treatment, gene Fold change Dex PRR16 11.71 GMPR 10.39 PNMT 9.46 TDRD9 8.84 PER1 8.60 FRMD4A -9.23 TMEM191B -15.05 NEUROG1 -16.06 ELF5 -19.49 ZNF775 -25.45 Gen CACNA1I 20.67 MSMB
19.54 NPPC 9.39 ALPPL2 9.24 CA12 8.95 FOXB1 -23.44 ATN1 -28.07 SYNPO -35.99 GRIN1 -37.20 ZNF775 -40.56 Dex + Gen MSMB
30.26 MICALCL 16.38 CACNA1I 15.48 CAMP 12.98 DHRS3 11.49 SP5 -17.21 NEUROG1 -17.68 TMEM191B -18.02 ELF5 -39.80 ZNF775 -45.33
US biopharmaceutical firm Amag Pharmaceuticals (NASDAQ:AMAG) said its board had snubbed the buyout bid by private equity firm MSMB
Capital Management, as it was not superior to its agreed tie-up with Allos Therapeutics (NASDAQ:ALTH).
's offer is conditioned on completion of cursory due diligence and other customary provisions.
level is affected by a genetic change linked to prostate cancer.
Shkreli is accused of mismanaging money at the investment funds Elea Capital, MSMB
Capital and MSMB
Healthcare, as well as while he was CEO of Retrophin (RTRX), a pharmaceutical company he founded in 2011.
His arrest, however, had nothing to do with the pill's exorbitance price increase but instead, alleged illegal practices during his time at both a pharmaceutical company and his hedge fund, MSMB
MILFORD - MSMB
Capital Management LP has made an unsolicited offer to take over SeraCare Life Sciences Inc.
Other SNPs that reached genome-wide significance were rs401681 and rs2736098 near the TERT (telomerase reverse transcriptase) gene on chromosome 5, rs10788160 near the FGFR2 (fibroblast growth factor receptor 2) gene, rs10993994 near the MSMB
(microseminoprotein, beta-) gene (as in prior studies) on chromosome 10, rs11067228 near the TBX3 (T-box 3) gene on chromosome 12, and rs4430796 at the HNF1B (HNF1 homeobox B) gene on chromosome 17.
In addition to security fraud, the 34-year-old is accused of wire fraud, conspiracy, and mismanaging money at his investment funds Elea Capital, MSMB
Healthcare, as well as while CEO of Retrophin (RTRX), the pharmaceutical company he founded in 2011.
Earlier this month, MSMB
, a long-term investor in Amag, has proposed to buy the rest of the company not yet owned at USD18.00 (EUR12.60) per share, or a total of USD378m, as it believed that the planned combination with Allos Therapeutics was not in the best interest of shareholders.