[8.] Barrera, S.M., et al., (Genotypic survey of Plasmodium falciparum based on the mspl, msp2
andglurp genes by multiplex PCR).
Anaplasma phagocytophilum has functional msp2
gene that is distinct from p44.
Variation of Plasmodium falciparum msp1 block 2 and msp2
allele prevalence and of infection complexity in two neighbouring Senegalese villages with different transmission conditions.
Sera samples were tested within ELISA kit (SNAP 4Dx, IDEXX Laboratories, USA) revealed antibodies reacting to immunodominant protein (msp2
) of A.
falciparum populations using antigenic genes msp1, msp2
, and glurp has been known to describe allelic variability within parasite populations and also to distinguish recrudescence from new infections of P.
In addition to the 16S rRNA locus, the major surface proteins (msp2
and mps4) and the ankA locus have been targeted in studies of the genetic variation between A.
The genetic characteristics of particular polymorphic genes, such as msp1, msp2
and glurp (1-3), have been applied to explore parasite population dynamics in malaria endemic areas.
For example, SPR has been shown to correlate with ELISA for AMA1, which binds with relatively high affinity, but not for MSP2
, which binds with lower affinity .
PCRs targeting msp1, msp2
, and glurp genes were used to differentiate recrudescence (same parasite strain) and reinfection (different parasite strain).
A phase 1 trial of MSP2-c1, a blood-stage malaria vaccine containing 2 isoforms of MSP2
formulated with montanide(r) isa 720.
Safety and immunogenicity of a three-component blood-stage malaria vaccine (MSP1, MSP2
, RESA) against Plasmodium falciparum in Papua New Guinean children.
For example, reactivity profiles in cluster 1 generally recognized AMA-1 and the 2 variants of MSP2
(FC27 and 3D7), and this cluster contained a statistically significantly higher number of children from the clinically immune group relative to the other clinically defined groups.