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MTHFDMethylenetetrahydrofolate Dehydrogenase
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Chen et al., "Polymorphisms of MTHFD, plasma homocysteine levels, and risk of gastric cancer in a high-risk Chinese population," Clinical Cancer Research, vol.
It is well-known that betaine is a methyl donor in the formation of methionine, a critical step in the formation of methyltetrahydrofolate catalyzed by methylene tetrahydrofolate dehydrogenase (MTHFD) [36].
Moreover, some studies reported that the combined MTHFR 677CT/TT and MTHFD1958AA/GA [41] and MTHFD 1958AA/RFC1 80GG genotypes [29] were significantly associated with the maternal risk for DS.