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There were 82 (34.2 %) responders in pre-operative, and 102 (42.5 %) in post-operative mVLT sessions.
There was no difference between the proportions of response patterns in pre- and post-operative mVLT sessions: there were 82 pre-operative MFCs with acPED [less than or equal to] 0 and 158 with acPED > 0 while there were 102 post-operative MFCs with acPED [less than or equal to] 0 and 138 with acPED > 0 (P = 0.074).
This retrospective observational study used the ROC curve and gray zone approaches to examine the accuracy of cPDE in the evaluation of hemodilution response to mini fluid challenges with crystalloids in the mVLT protocol.
There were 14 % MFCs with inconclusive cPDE predictions of response in two perioperative mVLT sessions.
Fluid challenge induced plasma dilution (PD) during the mVLT is calculated from a change of hemoglobin concentration (Hb).
According to the mVLT, a decision to make an additional fluid bolus is based on a difference between invasively (arterial) and nonivasively (capillary) measured plasma dilution efficacies, aPDE and cPDE, respectively.
According to the mVLT method, an additional fluid bolus is necessary only when acPED is positive.
Retrospective analysis of the data obtained from 48 patients during a 6-step mVLT protocol in our previous RCT revealed that fluctuation amplitude of noninvasive variables was much higher than of invasive.
The key variables were also obtained after the 20 min period without fluids that followed the last bolus in all mVLT sessions, that data point being referred to as EQ.
To determine the statistical bias, we used the data obtained at data points T0-T6 during a Pre-op mVLT in twenty five patients.
The Bland-Altman plot was used to demonstrate agreement between the paired SpHb and aHb values from both mVLT sessions in both groups (Fig.
The software in a computer of our semi-closed loop system implements the extended clinical algorithm for generating the following commands: (1) administer the vasopressor injection (automated, but can be objected), (2) perform the mVLT fluid protocol (semi-automated, requires physician's approval), (3) administer maintenance crystalloid infusion (semi-automated, requires physicians approval), (4) perform the red cell transfusion (semi-automated, requires physician's approval).
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