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MYF5Myogenic Factor 5
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Oct4 binds at the transcriptionally inactive Myf5 locus in ES cells [186], but recent ChIP-Seq analysis has shown that Oct4 does not bind to MyoD or the Pax7 locus in ES cells [187].
We examined expression of the myoblast markers, namely MyoD, Myf5, myogenin and desmin.
Myogenic properties of BSC were also determined by their mRNA expression levels of myogenic markers like MyoD, Myf5 and myogenin and Figure 2 shows the levels of all the three myogenic markers in BSC.
The process of myogenesis is regulated by a family of basic helix-loop-helix transcription factors, including MyoD and Myf5 (Weintraub et al., 1993; Emerson, 1993).
Myf5 expression in satellite cells and spindles in adult muscle is controlled by separate genetic elements.
Transcription factors C/EBPa and PPARy (Figure 5) identified quantitatively by real time PCR when porcine satellite cells were transdifferentiated in the presence of ciglitizone and when expressed in G8 myoblasts, can suppress the muscle-specific transcription factors (Myf5, MyoD, myogenin and MRF4) (Hu et al., 1995).
Muscle fiber formation takes place during embryonic development and is regulated by the MyoD gene family, which consists of four genes, MyoD1 (MYF3), myogenin (MYOG or MYF4), MYF5 and MYF6 (MRF4).
In addition, other myoblast markers, Myf5, MyoD, MyoG, FHL1, and NFATcl, were expressed in horse muscle cells, indicating that the cell population possesses myogenic features observed in other mammals; however, further investigation is required (Figure 2C).
Martindale et al., "Novel RNA-binding activity of MYF5 enhances Ccnd1/Cyclin D1 mRNA translation during myogenesis," Nucleic Acids Research, vol.
Vivarelli et al., "Differential activation of Myf5 and MyoD by different Wnts in explants of mouse paraxial mesoderm and the later activation of myogenesis in the absence of Myf5," Development, vol.
In chicken, it was described more as a myokine than an adipokine, because of its main expression in muscle and its ability to decrease the expression of MYF5 expression (a myogenic factor) in myoblasts [31].