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Another study using GMT with MESPl and MYOCD in human cardiac and dermal fibroblasts was sufficient to induce expression of multiple cardiac-specific proteins, increase a broad range of cardiac genes, and exhibit spontaneous calcium transients [22].
Similarly, when miRNA-133 was used in conjunction with GMT, Mespl, and Myocd or GHT, Myocd, and miRNA-1, the reprogramming efficiency was increased in both human and mouse fibroblasts by repressing Snai1 and silencing fibroblast gene signatures [35, 37].
Adler et al., "Transcription factors MYOCD, SRF, Mesp1 and SMARCD3 enhance the cardio-inducing effect of GATA4, TBX5, and MEF2C during direct cellular reprogramming," PLoS One, vol.