Examples are KLF4 mRNA and miR-206 in quiescent cells and Myt1
and miR-16 in immature oocytes, which are illustrated in Figure 2 [85,100,103,104].
A critical balance between Cyclin B synthesis and Myt1
activity controls meiosis entry in Xenopus oocytes.
We also examined activation of other kinases, Wee1 and Myt1
, that phosphorylate Cdc2 at Tyr15 to maintain Cdc2 in an inactive state.
Analysis of the SPP1 promoter sequence revealed putative transcription factor binding sites for SP1 around c.-66, for CBFA1/RUNX2 around c.-155, and for MYT1
zinc finger factor at c.-443 (Fig.