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GA is actively transported into human lysosomes via mannose-6-phosphate receptor-mediated endocytosis (5).
The reason for this low dose is that the enzyme produced by our Chinese Hamster Ovary (CHO) cell line has the proper structure of mannose-6-phosphate (M-6-P) ligand needed to ensure efficient uptake by the M-6-P receptors that are present on all of each patient's cells.
In this experiment, the effects of Mannitol and Mannose-6-Phosphate were tested on McCoy fibroblasts.