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MMP3Matrix Metalloproteinase 3
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Matrix metalloproteinase 3 in the supernatants of synovial tissue homogenates from RA and OA was also detectable in all the samples examined.
Matrix metalloproteinase 3 is induced by proinflammatory cytokines such as interleukin 1 and tumor necrosis factor a in rheumatoid synovial fibroblasts in culture.
CHICAGO -- Baseline plasma matrix metalloproteinase 3 levels predicted joint space narrowing over 16 months in patients with knee osteoarthritis, according to findings from a pilot study.
Kawata et al., "Novel transcription factor-like function of human matrix metalloproteinase 3 regulating the CTGF/CCN2 gene," Molecular and Cellular Biology, vol.
Bresnihan, "Early joint erosions and serum levels of matrix metalloproteinase 1, matrix metalloproteinase 3, and tissue inhibitor of metalloproteinases 1 in rheumatoid arthritis," Arthritis & Rheumatism, vol.
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