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MDR1Multi-Drug Resistance 1
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References in periodicals archive ?
Robak, "Distribution of allelic variants of functional C3435T polymorphism of drug transporter MDR1 gene in a sample of Polish population," Polish Journal of Pharmacology, vol.
earlier reported that ouabain treatment led to the induction of MDR1 expression [165] leading the latter authors to hypothesize that this likely occurred at sublethal doses.
Functional characterization of coding polymorphismsin the human MDR1 gene using a vaccinia virus expression system.
Many authors unveiled the transfection of MDR1 cDNA into epithelial or even non-epithelial cells down-regulated P-gp which resulted in cell swelling (Morin et al.
Maeda et al., "Role of P-glycoprotein in accumulation and cytotoxicity of amrubicin and amrubicinol in MDR1 gene-transfected LLC-PK1 cells and human A549 lung adenocarcinoma cells," Biochemical Pharmacology, vol.
Li, "MDR1 gene C3435Tpolymorphism is associated with clinical outcomes in gastric cancer patients treated with postoperative adjuvant chemotherapy," Asian Pacific Journal of Cancer Prevention, vol.
The ATP-binding cassette, subfamily B, member 1 (ABCB1), also named multidrug resistance gene 1 (MDR1), is located on chromosome 7q21.1.
Allele frequencies obtained for the present study were MTHFR 677T (10%) and 1298 C (30%), TS 3UTR 0bp (46%), MDR1 3435T and 1236T (62%), RFC1 80A (57%), GGH 401T (61%), MS 2756G (34%), ATIC 347G (52%) and SHMT1 1420T (80%).
In the years immediately following MDR1, extensive changes occurred in data recording and encoding standards.
As the disease evolves, genetic mutations in addition to BCR ABL are produced in leukemic cells, thus diminishing the effect of Imatinib17.Various mutations including hOCT1 (human organic cation transporter-1), MDR1 (multi drug resistance gene-1), ABCB1, ABCG2 alter the intracellular concentration of TKI.
Lack of an effect of CYP3A4 and MDR1 gene polymorphisms on colchicine pharmacogenetics in the treatment of Familial Mediterranean fever.
This tests for both breed and MDR1, a multi-drug resistance genetic mutation that can lead to negative reactions to commonly prescribed medications.