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MeCP2Methyl CpG (Cytosine Phosphate Guanine) Binding Protein 2
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MeCP2 is a transcriptional repressor with abundant binding sites in genomic chromatin.
But that number dropped to 26% of the professionals being in favor of an optional newborn testing of the MECP2 gene.
Kipnis and his team discovered that when microglia lack properly functioning Mecp2, they are unable to perform this crucial duty efficiently.
The molecular diagnosis of MECP2 mutations has been complex and expensive, depending on mutation identification using a scanning technique followed by DNA sequencing.
Girls with Rett syndrome have a defective MECP2 gene on one of their two X chromosomes and a sound gene on the other.
As Francke and five other scientists report in the October issue of Nature Genetics, the gene instructs cells throughout the body to make a protein known as methyl-CpG-binding protein 2 -- MeCP2 for short.
London, Jan 9 (ANI): Overexpression of two genes is responsible for the anxiety and behavioural issues associated with excess MeCP2 protein, say scientists.
L1 retrotransposition in neurons is modulated by MeCP2.
Diagnostic testing for Rett syndrome by dHPLC and direct sequencing analysis of the MECP2 gene: identification of several novel mutations and polymorphisms.
According to a recent study in rats, researchers at the Scripps Research Institute found that cocaine consumption increased levels of a regulatory protein called MeCP2 that shuttles back to the nucleus to influence gene expression in the brains of rats.
In the current study, the researchers focused on a gene called MECP2 because it plays major roles in controlling brain development.
We studied not only the gene itself - a gene called MECP2, which is known to have a big effect on brain development - but also the regions surrounding the gene, sometimes known as junk DNA," said principle investigator Dr.