MeCP2


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AcronymDefinition
MeCP2Methyl CpG (Cytosine Phosphate Guanine) Binding Protein 2
References in periodicals archive ?
Modeling Rett syndrome using TALEN-Edited MECP2 mutant cynomolgus monkeys.
The study authors note that the gene MECP2 "is known to affect anxiety behaviors."
Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription.
The team has so far raised more than PS15,000 for the Reverse Rett charity, which directs the funds towards the research that is taking place into reversing both Rett and MeCP2 Duplication Syndrome.
Most females with Rett syndrome have known MECP2 (methyl CpG binding protein 2) mutations.
(19) showed the overexpression of miR-155 in the fibroblasts of discordant monozygotic twins and also confirmed that miR-155 was associated with cognitive impairment in individuals with DS by regulation of the MeCP2 gene (18,20).
West, "Regulation and function of MeCP2 Ser 421 phosphorylation in U50488-induced conditioned place aversion in mice," Psychopharmacology, vol.
Heintz, "MeCP2 binds to 5hmC enriched within active genes and accessible chromatin in the nervous system," Cell, vol.
Rett syndrome, although rare in males, was ruled out at the age of 4 by sequencing and deletion/duplication analysis of the MECP2 gene.
As noted in previous reports, the most notable gene in the Xq28 region is the methyl-CpG binding protein 2 gene (MECP2) [3].
Cheng et al., "Melittin induces PTCH1 expression by down-regulating MeCP2 in human hepatocellular carcinoma SMMC-7721 cells," Toxicology and Applied Pharmacology, vol.
Specificity of antinuclear autoantibodies recognizing the dense fine speckled nuclear pattern: Preferential targeting of DFS70/LEDGFp75 over its interacting partner MeCP2. Clin Immunol 2015; 161: 241-250.