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References in periodicals archive ?
Ruthenium red also inhibits [Ca.sup.2+] release from intracellular stores (Chamberlain et al., 1984; von Dassow and Latz, 2002; Jain and Sharma, 2016), and both ruthenium red and [Gd.sup.3+] inhibit some voltage-gated [Ca.sup.2+] channels (Lacampagne et al., 1994; Malecot et al., 1998), as well as Piezo channels, a recently discovered mechanosensitive ion channel conserved from protozoa to mammals (Coste et al., 2010, 2012; Prole and Taylor, 2013; Volkers et al., 2015).
polyedra, including compounds directed against mammalian TRP subfamilies TRPV, TRPM, and TRPC, as well as general inhibitors of mechanosensitive ion channels (Table 1).
The mechanosensitive ion channels (MsC) in the skeletal muscle are activated by membrane stretch and strong membrane depolarization and are permeable to [Na.sup.+] and divalent cations [40].
This phenomenon, termed mechanoelectric coupling, has been attributed to the presence of mechanosensitive ion channels that are activated by stretch or pressure changes within the myocardium.
We demonstrate that adhesion of endothelial cells to nanostructured PET substrates activates [beta]-catenin by enhanced tyrosine phosphorylation and calcium signaling through mechanosensitive ion channels.
Although it is possible to imagine how mechanosensitive ion channels might contribute tension-sensitive regulation of plasma membrane area, the most streamlined system would respond to tension with no intermediary chemical or voltage signals.