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MC4RMelanocortin 4 Receptor
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Expression of melanocortin 4 receptor mRNA in the central nervous system of the rat.
Przewlocki, "Melanocortin 4 receptor is expressed in the dorsal root ganglions and down-regulated in neuropathic rats," Neuroscience Letters, vol.
The total content of adenine and thymine (A+T) in the nucleotide sequence of the melanocortin 4 receptor gene was 50.17%, while the total content of guanine and cytosine (G+C) was 49.83%.
Prevalence of mutations and functional analyses of melanocortin 4 receptor variants identified among 750 men with juvenile-onset obesity.
(4) AGRP acts as an endogenous inverse antagonist of melanocortin 4 receptor (MC4R) gene.
This locus is approximately 150 kb downstream from MC4R, the melanocortin 4 receptor gene, which has long been suspected as a candidate for weight-related phenotypes, including antipsychotic-induced weight gain.
Two studies published last March in the NEJM focused on the melanocortin 4 receptor gene.
Previous studies in animals associated binge eating with a mutation of the gene for a brain protein called melanocortin 4 receptor (MC4R).
AMAG Pharmaceuticals announced that the FDA has accepted its New Drug Application, or NDA, for bremelanotide, a first-in-class melanocortin 4 receptor agonist designed for the treatment of hypoactive sexual desire disorder, or HSDD, in premenopausal women.
Melanocortin 4 receptor mutations in obese Czech children: studies of prevalence, phenotype development, weight reduction response, and functional analysis.
Lasaga, "Astrocytes: new targets of melanocortin 4 receptor actions," Journal of Molecular Endocrinology, vol.