Late-onset cerebellar degeneration in mice induced transplacentally by methylnitrosourea
is a known prostate carcinogen, and it would be interesting, Huff postulated, to expose strains of rats and mice to this agent to find an animal that would be a good model for prostate-specific carcinogens.
Whether the same mechanism is involved in the increase in number and incidence of methylnitrosourea
(MNU)-initiated tumors after neonatal TCDD exposure on PND 18 (Desaulniers et al.
Effect of dietary undegraded carrageenan on colon carcinogenesis in F344 rats treated with azoxymethane or methylnitrosourea
On day 21, all treatment groups, except for a control group and a 1,000-mix group, received a single intraperitoneal injection of methylnitrosourea
(MNU, 30 mg/kg bw), the initiator of the carcinogenic process.