Inhibition of methylnitrosourea
(MNU) induced oxidative stress and carcinogenesis by orally administered bee honey and Nigella grains in Sprague-Dawley rats.
Late-onset cerebellar degeneration in mice induced transplacentally by methylnitrosourea
. Teratog Carcinog Mutagen 7:449-463.
is a known prostate carcinogen, and it would be interesting, Huff postulated, to expose strains of rats and mice to this agent to find an animal that would be a good model for prostate-specific carcinogens.
Whether the same mechanism is involved in the increase in number and incidence of methylnitrosourea
(MNU)-initiated tumors after neonatal TCDD exposure on PND 18 (Desaulniers et al.
Effect of dietary undegraded carrageenan on colon carcinogenesis in F344 rats treated with azoxymethane or methylnitrosourea
. Cancer Res 38:4427-4430 (1978).
On day 21, all treatment groups, except for a control group and a 1,000-mix group, received a single intraperitoneal injection of methylnitrosourea (MNU, 30 mg/kg bw), the initiator of the carcinogenic process.
Thus, our objective was to determine whether exposure to this mixture by gavage from neonatal day 1 to day 20, or whether a single exposure to TCDD at neonatal day 18 could modulate the development of methylnitrosourea (MNU)-induced mammary tumors.