"Our results may be clinically relevant and support annual blood tests for all individuals diagnosed with MGUS
or light-chain MGUS
," the authors write.
The study population was limited to 781 white, male WTC-exposed firefighters aged 50 to 79 whose blood samples were evaluated to assess the prevalence of MGUS
in the group.
When ordering an SPE to rule in/out MGUS
, it's essential to also order serum free light-chain testing, because it provides key prognostic information.
Conclusion: In this study MGUS
is seen to be more prevalent in our patients particularly in older age group.
In our case, the most common causes of NB myopathy, either hereditary or acquired, were ruled out by molecular-genetic testing of ACTA1 and NEB genes, screening for HIV infection and MGUS
. Nonetheless, at present we cannot rule out with certainty the possibility of mutations in genes less frequently involved in NB myopathy (i.e., TPM3) that could produce a "double-trouble" effect, at least on the genetic and histopathological ground.
CD4/CD25/FoxP3 (% of Increased in MM versus  [CD4.sup.+] cells) MGUS
(trend without statistical significance) Feyler et al.
Diagnoses included MGUS
(five persons), myeloma (four), WM (three), and immunoglobulin light chain amyloidosis (one).
The prognostic significance of t(4;14) as detected by RT-PCR on BM and PB samples of 208 patients with MM and 52 patients with monoclonal gammopathy of undetermined significance (MGUS
) was assessed.
The patient may have a coincidental monoclonal gammopathy of undetermined significance (MGUS
) which may or may not be the result of a reactive immunologic process.
For instance, one study calculated the number of Tregs in the peripheral blood (PB) of controls versus subjects with MGUS
and MM and displayed a significant decrease in the number of Treg cells.
Many, if not all, myeloma patients are considered to have harbored a premalignant monoclonal gammopathy of undetermined significance (MGUS
) that progresses to smoldering or asymptomatic multiple myeloma and ultimately to symptomatic multiple myeloma requiring therapeutic intervention .
Jude 25 and a new dacron patch), respectively, for severe aortic regurgitation and interventricular defect recurrence (Laubry-Pezzi syndrome), permanent atrial fibrillation in oral anticoagulant therapy, chronic liver disease (HCV-related), monoclonal gammopathy of undetermined significance (MGUS
), pancytopenia, severe mitral and tricuspid regurgitation with pulmonary hypertension, and a previous admission with a diagnosis of heart failure with preserved ejection fraction (HFpEF).