Microphthalmia-associated transcription factor
as a regulator for melanocyte-specific transcription of the human tyrosinase gene.
Furthermore, a-melanocyte-stimulating hormone (a-MSH) and cAMP-elevating agents, such as forskolin and IBMX, through the activation of protein kinase A (PKA) and cAMP-related element binding protein (CREB) transcription factor, promote an increase in the expression of microphthalmia-associated transcription factor (MITF), a master regulator of the development and differentiation of melanocytes.
The microphthalmia-associated transcription factor Mitf interacts with beta-catenin to determine target gene expression.
Microphthalmia-associated transcription factor demonstrated a cytoplasmic blush in tumor cells.
Cytoplasmic staining by microphthalmia-associated transcription factor in our case was regarded as nonspecific, and could not be used to determine melanocyte differentiation.
1-4) They are also known to be positive for other melanocytic markers such as HMB-50, Mart-1/ Melan-A, tyrosinase, and microphthalmia-associated transcription factor (Figure 1, C).
Immunohistochemical and reverse transcription-polymerase chain reaction expression analysis of tyrosinase and microphthalmia-associated transcription factor in angiomyolipomas.
The transcription factor binding to IGHM enhancer 3 (TFE3) protein belongs to a family of basic helix-loop-helix/leucine zipper transcription factors that also includes transcription factor EB (TFEB), transcription factor EC, and microphthalmia-associated transcription factor