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References in periodicals archive ?
Depending upon which MMR gene is mutated, the sensitivity of microsatellite instability for diagnosing HNPCC ranges between 55% and 91%, but it is at the higher end of the range for the more commonly involved genes.
Microsatellite instability and mismatch repair protein defects in ovarian epithelial neoplasms in patients 50 years of age or younger.
Hawkins, "Adverse prognostic effect of methylation in colorectal cancer is reversed by microsatellite instability," Journal of Clinical Oncology, vol.
The site of the tumour was noted, as were histopathological features suggestive of microsatellite instability.
Microsatellite instability testing protocols are similar to those developed for colon cancer.
Loss of ARID1A expression and its relationship with PI3K-AKT pathway alterations, TP53 and microsatellite instability in endometrial cancer.
Commercial immunohistochemistry and microsatellite instability analysis showed absence of MLH1 and PMS2 protein expression and that the tumor was MSI-High.
Tesaro summarized updated Phase 1 GARNET data of TSR-042 in patients with recurrent or advanced microsatellite instability high endometrial cancer during the European Society for Medical Oncology Congress.
Type I OvCAs are suggested to be low-grade and characterized by mutations in PTEN and CTNNB1, and microsatellite instability, while Type II tumors include high-grade serous carcinomas and undifferentiated carcinomas, which typically contain mutations in p53, BRCA1 and BRCA2.
In the largest comparison of blood-based microsatellite instability testing to traditional tissue methods across multiple solid tumor types, researchers demonstrated that the Guardant360 assay can accurately detect MSI, an important biomarker used to predict response to immunotherapy regardless of tumor type.
* Microsatellite instability: Detecting cells deficient in DNA repair capabilities, microsatellite instability-high (MSIH), or mismatch repair deficient (dMMR) in solid tumors.